Antibody Engineering Manager

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Reporting to the Operations Manager, the role of Antibody Engineering Manager will be responsible for all aspects of protein engineering, particularly monoclonal antibody drugs. This will include multi-specific antibody design, affinity maturation, protein-protein docking, developability analysis, humanization and antigen design. The Antibody Engineering Manager will manage a team of scientists while acting as a liaison with other business units.

Primary Position Responsibilities/Tasks:

  •     Responsibility for planning, implementation and management of projects (including liaising with clients on a weekly basis).
  •     Share and discuss data with management to ensure production demands are met within agreed timelines.
  •     Responsible for the line management and development of other scientific staff within Fusion (support and supervision, training, staff appraisals etc).
  •     Ensuring reports/results shared with clients are of a high standard.
  •     Responsible for addressing all aspects of Antibody Engineering within the company including Antibody Humanization, Antibody Developability, Multispecific Antibody Reformatting and Antibody Affinity Maturation (RAMP).
  •     Work cohesively with the R&D team to develop new innovative Antibody Engineering technology.
  •     Responsible for introducing state of the art technology into the antibody engineering workflow including machine learning for drug discovery and optimization.
  •     Responsible for overseeing antigen design and working cohesively with the Discovery Team to ensure client expectations are met.
  •     Responsible for working cohesively with the Production team to ensure the smooth transition of vital information between teams.
  •     Keep abreast of advancements within their area of expertise.
  •     Ensure proprietary and external software in the Antibody Engineering department is up to date and functioning optimally.
  •     Prepare and present oral and written reports on research activities to internal and external audiences. To act of the main point of contact for Fusion clients.
  •     Provide technical consultancy to the business development team and lead technical calls with prospective and current clients.
  •     Be proactive with their own CPD (continued personal development).
  •     Ensure that all duties are performed in accordance with organisational standards, policies and procedures.
  •     Perform other duties as assigned.

Job Specification

Essential Criteria:

  •     PhD in Bioinformatics, Computational Chemistry/Biology or related field, or MSc with 1+ years of industry experience.
  •     Key skills of the post holder include project management and excellent communication
  •     Experience with MS office applications.

Desirable Criteria:

  •     Industrial experience in computational biology, immuno-informatics, protein engineering, or structural biology.
  •     Familiar with machine learning methods used in protein/antibody engineering.
  •     Software engineering skills, especially with the Python programming language.
  •     Familiar with NGS repertoire analysis.
  •     Have the ability to mentor more junior members of the team and also be able to share your specialist knowledge with those you collaborate with.
  •     Familiarity with working in an ISO 9001:2015 environment.

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